DOBUTAMINE HYDROCHLORIDE

PRODUCT IDENTIFICATION
CAS NO. 49745-95-1

DOBUTAMINE HYDROCHLORIDE

EINECS NO. 256-464-1
FORMULA C18H24NO3
MOL WT. 337.85

H.S. CODE

  

TOXICITY

 
SMILES

 
SYNONYMS  
4-[2-[3-(4-hydroxyphenyl)-1-methylpropyl] amino]ethyl]-1,2-benzenediol, hydrochloride; 4-[2-[(RS)-3-(4-hydroxyphenyl)-1-methylpropylamino] ethyl]-benzene -1,2-diol, hydrochloride;
SMILES

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white crystalline powder
MELTING POINT  
BOILING POINT

 

SPECIFIC GRAVITY

 

SOLUBILITY IN WATER Soluble (soluble in alcohol and in pyridine)
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

 

REFRACTIVE INDEX

 

FLASH POINT

 

STABILITY

Stable under ordinary conditions. Hygroscopic.

APPLICATIONS
Dobutamine is a synthetic catecholamine used as an adrenergic to treat congestive heart failure and cardiogenic shock. Catecholamines are biogenic amines considered as sympathomimetic drugs; the aromatic portion of whose molecule is catechol, and the aliphatic portion an amine; examples are dopamine, epinephrine, isoproterenol and norepinephrine. Epinephrine and dopamine can be obtained naturally. Chemically, dobutamine is described as 4-[2-[3-(4-hydroxyphenyl)-1-methylpropyl] amino]ethyl]-1,2-benzenediol. The hydrochloride salt of dobutamine is injectable.

Tyramine [4-(2-Aminoethyl)phenol] is a monoamine compound of 4-hydroxy phenethylamine. It is derived from tyrosine, an amino acid (protein building block) that is the precursor of norepinephrine. It, through its effect on neurotransmitters, may affect several health conditions, including Parkinson's disease, depression, alcohol withdrawal support, and Phenylketonuria. (PKU). Tyramine is naturally found in plant and animal tissues, certain cheeses and ergot or produced synthetically. It is metabolized by monoamine oxidase. Tyramine or its derivatives can be used in pharmaceutical industry such as:

  • Sympathomimetic or adrenergic drugs themselves or intermediate of them.
  • Intermediate for bezafibrate used in the treatment of high cholesterol levels.
  • Determination of peroxide activity in the fluorescence enzyme immunoassay for insulin.
  • False transmitter.

Tryptamine [3-(2-Aminoethyl)indole] is a biologically important monoamine compound derived  by the decarboxylation of tryptophan, indole side chain amino acid. In addition to its function to build the structure of protein, tryptophan is a precursor for neurotransmitter and neurohormone. Tryptamine (biological monoamine) effects vasoconstriction by causing the release of norepinephrine at postganglionic nerve endings. Several mental disorders and health conditions are explained as due to either an excess or deficiency of monoamines. There are many natural tryptamines in both animal and plant as well as synthetics modified by chemical constituents and substituted at appropriate positions in the motif. Common tryptamine class compounds include;

  • Bufotenine (CAS #: 487-93-4): (5-Hydroxy-N,N-dimethyltryptamine, pressor agent, epinephrine-like.
  • DMT (CAS #: 61-50-7): N,N-Dimethyltryptamine, a psychedelic and hallucinogenic.
  • Luzindole (CAS #: 117946-91-5): N-Acetyl-2-benzyltryptamine
  • Melatonin (CAS #: 73-31-4, 8041-44-9): N-Acetyl-5-methoxytryptamine, biological clock hormone.
  • Psilocin: 4-Hydroxy-N,N-dimethyltryptamine.
  • Psilocybin (CAS #: 520-52-5): 4-Phosphoryloxy-N,N-dimethyltryptamine, a hallucinogenic.
  • Serotonin (CAS #: 50-67-9): 5-Hydroxytryptamine, a vasoconstrictor.
  • Sumatriptan( CAS #: 103628-46-2) 4-Hethylaminosulfonyl-N,N-dimethyltryptamine, selective serotonin antagonist used in the treatment of migraine headache.
SALES SPECIFICATION

BIBLIOGRAPHY

USP

APPEARANCE

 white to off-white crystalline powder

ASSAY

 98.0 - 102.0% (on anhydrous basis)

SOLUTION CLARITY

pass
RESIDUE ON IGNITION

0.2% max
WATER

1.0% max

HEAVY METALS

20ppm max
TRANSPORTATION
PACKING
25kgs in Fiber Drum
HAZARD CLASS Not regulated
UN NO.  

GENERAL DESCRIPTION OF CATECHOLAMINE
Catecholamine: a group of naturally occurring sympathomimetic amines that have important physiological functions within the body as neurotransmitters in the central nervous system and hormones in the blood circulation. Catecholamines are biogenic amines considered as sympathomimetic drugs; They are characterized by a catechol group [The ortho (1,2) isomer of dihydroxybenzene] to which is attached an amine group (the aromatic portion of whose molecule is catechol, and the aliphatic portion an amine). The most abundant catecholamines in the body are epinephrine (adrenaline), norepinephrine (noradrenaline) and dopamine. They are derived from the tyrosine, an amino acid (protein building block) that is the precursor of norepinephrine. (The prefix nor- describes normal structure which has no branched chain of carbon atoms. In case of norepinephrine, it has one less methylene group than its homologue, epinephrine.) Catecholamines belong to a broader class of compounds called phenethylamines which contain structurally amino acid, phenylalanine and tyrosine. Phenethylamine is a backbone for the compounds which take roles of alkaloids as well as hormones and neurotransmitters in nature.  Amphetamine is the substituted phenethylamine by methyl group at alpha position. It  is a synthetic drug used as a diet suppressant and to treat narcolepsy and ADHD (attention deficit hyperactivity disorder). But amphetamines can produce severe psychological dependence, including cardiac irregularities and gastric disturbances. Chronic use often results in extreme exhaustion and malnutrition.  Substituted phenethylamines are:

PHENETHYLAMINES